CLINICAL TRIALS AND OBSERVATIONS Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children’s Oncology Group CCG-1952 clinical trial

نویسندگان

  • Linda C. Stork
  • Yousif Matloub
  • Emmett Broxson
  • Mei La
  • Rochelle Yanofsky
  • Harland Sather
  • Ray Hutchinson
  • Nyla A. Heerema
  • April D. Sorrell
  • Margaret Masterson
  • Archie Bleyer
  • Paul S. Gaynon
چکیده

1Division of Hematology-Oncology, Doernbecher Children’s Hospital/Oregon Health & Science University, Portland; 2Division of Hematology-Oncology, Rainbow Babies & Children’s Hospital, Case Western Reserve University, Cleveland, OH; 3Division of Hematology-Oncology, The Children’s Medical Center/Wright State University Boonshoft School of Medicine, Dayton, OH; 4Children’s Oncology Group, Statistical Office, Arcadia, CA; 5Division of Pediatric Hematology-Oncology, CancerCare Manitoba, Winnipeg, MB; 6Division of Hematology-Oncology, C. S. Mott Children’s Hospital/University of Michigan, Ann Arbor; 7Department of Pathology, Ohio State University, Columbus; 8Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA; 9Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick; 10St Charles Medical Center, Bend, OR and Oregon Health & Science University, Portland; and 11Division of Hematology-Oncology, Childrens Hospital Los Angeles, CA

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Prognostic Importance of 6-Mercaptopurine Dose Intensity in Acute Lymphoblastic Leukemia

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Clinical Trials and Observations: Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201

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We evaluated differences in outcome by ethnicity among children with acute myeloid leukemia (AML). We analyzed 791 children in the CCG 2891 trial and confirmed positive findings in 850 children in the CCG 2961 trial. Hispanic and black children treated with chemotherapy in CCG 2891 had significantly inferior overall survival (OS) from study entry compared with white children (37% 9% vs 48% 4% [...

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تاریخ انتشار 2010